Sunday 17 April 2011 Y 06:59

Protection against Prostate Cancer

The incidence of prostate cancer is much lower in Asian than Western populations, and soy foods may be one important reason why, suggests research published in Cancer Epidemiological Biomarkers and Prevention (Kurahashi N, Iwasaki M, et al.)
A 9-year Japanese study involving 43,509 men ranging in age from 45 to 74 years found that those eating the most soy food and miso (and therefore consuming more genistein and daidzein, the isoflavones found in soybeans) had a significantly lower risk of localized prostate cancer.
Among the men who were older than 60, the protective effect was strongest. Men whose diets provided the most genistein had a 48% reduced risk of localized prostate cancer compared to men food delivered the least of this isoflavone. Similarly, men consuming the most daidzein and soy foods showed 50% and 48% reduced risks of localized prostate cancer, respectively, compared to men consuming the least daidzein and soy foods.
Research suggests that isoflavone phytonutrients found in soybeans may protectively alter men's metabolism of estrogen, lowering men's ratio of 2 hydroxy estrogens to 16 hydroxyestrone (2:16 OH-E1). (Yes, real men produce some estrogen, and in men, the prostate is the primary locus of estrogen production.) Since the 2 hydroxy metabolites of estrogen are less likely to initiate hormone-related cancers than estrogen's 16 hydroxyestrone metabolites, soy's effect of increasing the amount of 2 hydroxy estrogen produced in relation to the amount of 16 hydroxyestrone made in the prostate may help prevent prostate cancer. (Hamilton-Reeves JM, Rebello SA, et al., J Nutr.)
Earlier research linking soy to protection against prostate cancer has suggested that the weak estrogenic activity of soy's isoflavones, which may act to reduce testosterone levels and inhibit 5-alpha-reductase (an enzyme involved in converting testosterone to its most potent form, DHT, which has been linked to prostate growth and male baldness), might also be protective. (Kurahashi N, Iwasaki M, et al., Cancer Epidemiol Biomarkers Prev.)
Practical Tips: Protect your prostate health by making soy foods a staple part of your healthy way of eating. Not a fan of tofu? Soy milk is now an available option, even at most espresso stands. You can take packets of miso to work with you, just as you would any dehydrated soup mix. Miso not only makes a delicious broth on its own, but can be sprinkled like seasoning over brown rice or any grain, any soup, or saut¨¦ed vegetable to add great flavor. Try a tofu burger for lunch. Experiment with a few brands till you find one you really enjoy; some (we like BocaBurgers) now do a pretty reasonable job of mimicking the taste and texture of beef. Soy nuts can also go with you to the office for a quick snack.